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Lake Mary / Orange City / Oviedo (407) 391-3344


Nerve testing

Testing For Neuropathy

The Epidermal Nerve Fiber Density (ENFD) test is an objective method of analyzing small fiber peripheral neuropathy by quantifying the terminal branches of peripheral nerves within the epidermis. In other words, we can see how many nerve endings are underneath your skin.

This test has a  97% of accuracy rate. The test is recommended to perform when patients experience the following symptoms: pain and abnormal sensation (burning, prickling, shooting), as well as numbness, tightness, coldness in foot/ankle areas.

The common causes of small fiber peripheral neuropathy are: diabetes, types I & II; HIV; vibratory trauma; amyloidosis / monoclonal gammopathy; alcohol abuse; pharmacologic toxins (metronidazole); solvent exposure, and idiopathic neuropathy, when the cause can’t be determined, once thought to represent as much as half of all cases.

 The ENFD test can also be used to predict the small nerve fiber peripheral neuropathy. A small 3×3 mm skin biopsy is used for providing diagnostic information on small nerve fibers. The ENFD biopsy is superficial with a very low risk for infection.

Epidermal Nerve Fiber Density Analysis

laughing  Uses a simple 3 mm punch biopsy of skin

laughing  Objectively diagnose small fiber peripheral neuropathy

laughing  Establish qualitative and quantitative baselines

laughing  Predict the onset of neuropathy in person at risk

laughing  Monitor the therapeutic effect of surgical and medical treatment





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